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Jan
2021

potassium thiocyanate blood pressure

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Br Heart J. No data available. Skin Contact: Causes irritation to skin. The effects of thiocyanate on basal and supplemental blood pressures. 2 Names and Identifiers Expand this section. When it comes to fighting high blood pressure, the average American diet delivers too much sodium and too little potassium. However, it contains a cyanogenic glucoside, linamarin, that is hydrolyzed in two steps: the linamarin is first hydrolyzed to acetone cyanohydrin and glucose (catalyzed by the enzyme linamarase), and then the acetone cyanohydrin is hydrolyzed to acetone and hydrogen cyanide (HCN). Potassium thiocyanate is a potassium salt which is the monopotassium salt of thiocyanic acid. Terms of Use| From the Department of Pathology of Washington University School of Medicine and the St. Louis County Hospital. Methonium compounds in the treatment of hypertension. 1947 Apr 5;1(6449):465. doi: 10.1016/s0140-6736(47)91970-3. An acute inhalation study is not available but inhalation is not a likely route of exposure due to the low vapour pressure, hygroscopic properties of the substance and the way of use. These amazing seeds may cause a low blood pressure reaction due to the formation of potassium thiocyanate (also known as thiocyanic acid), which is a potent blood pressure-lowering agent. The probable lethal dose is between 15-30 grams. Since Westphal1 in 1925 reintroduced the use of potassium thiocyanate for the treatment of hypertension, varying and conflicting reports have appeared in the literature concerning the merits of this treatment. That this opinion is shared by other clinicians and that the thiocyanate treatment of hypertension is becoming more generally used is seen from the number of recent publications to that effect.4 However, others have felt that thiocyanates were not only dangerous5 in the treatment of hypertension but useless.6 The toxic manifestations encountered in clinical practice with thiocyanate are well known and have been carefully considered by Wald7 and others. A diet that includes potassium-rich fruits and vegetables is good for the heart. Symptoms may include coughing, shortness of breath. Contents. As a result, potassium builds up in your blood. Hazards Identification. Just like potassium, too much magnesium can be lost in urine due to diuretic use, leading to low magnesium levels. Low potassium (hypokalemia) has many causes. 1. Solid Vapor Pressure Vapor Density Specific Gravity / Density <1 hPa @ 20 °C Not applicable 1.886 Solid Bulk Density 750 - 1000 kg/m 3 Water Solubility 2170 g/L (20°C) After four to ten days the potassium thiocyanate is given, if the necessary indications for its use are still present, in a dose of 2.1 g. weekly. This product is available only to Canadian customers. The compound has a low melting point relative to most other inorganic salts. Since the introduction of blood level checks in thiocyanate therapy by Barkers in 1936, twenty-one favorable and five unfavorable reports on its efficacy in human hypertension have been listed.' Eye Contact: Causes irritation, redness, and pain.  |  Potassium thiocyanate apparently caused actual increases ill symptoms and blood pressure in a minority of cases. Chronic Exposure: Blood Pressure* Blood Pressure Determination* Hypertension* Thiocyanates* Substances. FATAL POISONING FROM POTASSIUM THIOCYANATE TREATMENT OF HYPERTENSION: REPORT OF A CASE AND REVIEW OF THE LITERATURE. doi: 10.1371/journal.pone.0214476. At the end of one week's treatment the serum thiocyanate concentration is estimated. Please enable it to take advantage of the complete set of features! National Center for Biotechnology Information, Unable to load your collection due to an error, Unable to load your delegates due to an error. Low potassium is associated with a risk of high blood pressure, heart disease, stroke, arthritis, cancer, digestive disorders, and infertility. 4. 1947 May 3;1(4504):595-8. HHS Customize your JAMA Network experience by selecting one or more topics from the list below. Stethoscopes and blood pressure instruments; Physiology activity labs; Professional medical scales; Health practices; Blood typing; Sexual education; Dissection. the part of the casual blood pressure that ieflects the physical, emotional, and metabolic activity of the patient at the time (Alamet al., 1943). Proc Staff Meet Mayo Clin. Potassium thiocyanate is the chemical compound with the molecular formula KSCN. Br Med J. May cause vomiting, disorientation, weakness, low blood pressure, convulsions, psychosis, and death. This was striking to all observers, for the patient would now help in ward duties and could walk about without giddiness. © 2021 American Medical Association. there was great relief in the attacks of giddiness and in the headaches. © 2021 American Medical Association. Symptoms include redness, itching, and … The most common cause is excessive potassium loss in urine due to prescription medications that increase urination. May cause psychosis, vomiting, disorientation, weakness, low blood pressure, convulsions and death which may be delayed. Potassium thiocyanate Revision Date Oct-2018 Evaporation Rate Flammability (solid,gas) Explosion Limits Not applicable No information available. Often a report of high blood potassium isn't true hyperkalemia. ment on the patient's well-being and blood pressure is noted. The hexamethonium compounds in the treatment of hypertension. to download free article PDFs, Because of the well recognized toxic effects, RUSSELL WO, STAHL WC. Barker2 in 1936 reported favorably on the use of thiocyanate for the treatment of hypertension and again3 in 1941 reaffirmed his opinion from a study of 246 patients observed for periods ranging from two to ten years. USA.gov. In an acute dermal toxicity study with potassium thiocyanate no mortalities occurred and the LD50 is >2000 mg/kg bw. Normal body levels of potassium are important for muscle function. BLOOD PRESSURE DROP DURING THIOCYANATE ADMINISTRATION, AND BLOOD PRESSURE RISE AFTER WITHDRAWAL OF THE DRUG, IN THE FIFTY HYPERTENSIVE PATIENTS EXTENT OF FALL Fall during thiocyanate period (No. The probable lethal dose is … Skin Contact: May be harmful if absorbed through skin. The probable lethal dose is between 15-30 grams. Experience with potassium thiocyanate as a therapeutic agent in arterial hypertension. Get the latest public health information from CDC: https://www.coronavirus.gov, Get the latest research information from NIH: https://www.nih.gov/coronavirus, Find NCBI SARS-CoV-2 literature, sequence, and clinical content: https://www.ncbi.nlm.nih.gov/sars-cov-2/, NLM The thiocyanate ion [CNS—] was first used therapeutically in References Abstract S ince Westphal 1 in 1925 reintroduced the use of potassium thiocyanate for the treatment of hypertension, varying and conflicting reports have appeared in the literature concerning the merits of this treatment. Potassium thiocyanate is the chemical compound with the molecular formula KSCN. 1951 Apr 14;1(4710):778-84. doi: 10.1136/bmj.1.4710.778. It contains a thiocyanate. Thirty-two patients, selected because ofa certain degree ofhypertension, were investigated and were treated with potassium thiocyanate in doses varying from03 to 09 g. daily, mostofthemfor over nine months. There are also data from a meta-analysis that showed that a 1.6-gram increase in potassium intake per day could lower risk of stroke by as much as 21%. 1942;119(15):1177–1181. ... Potassium; Potassium Thiocyanate; Potassium Thiocyanate. OSHA Vacated PELs: Potassium thiocyanate: No OSHA Vacated PELs are listed for this chemical. In addition to conditions like kidney disease, these factors also contribute to hyperkalemia: A high-potassium diet, which can result from potassium supplements and salt substitutes. Symptoms include redness, itching, and pain. In the animals that died, the blood concentration of thiocyanate exceeded 20 mg per 100 cc. eCollection 2019. Inhalation: Causes irritation to the respiratory tract. Medications that contain potassium, such as certain high blood pressure medicines. Choose from: $ 18.75; Part no. May cause psychosis, vomiting, disorientation, weakness, low blood pressure, convulsions and death which may be delayed. Potassium thiocyanate in the treatment of hypertension. Our website uses cookies to enhance your experience. Skin Contact: Causes irritation to skin. All Rights Reserved, 1942;119(15):1177-1181. doi:10.1001/jama.1942.02830320023006, Challenges in Clinical Electrocardiography, Clinical Implications of Basic Neuroscience, Health Care Economics, Insurance, Payment, Scientific Discovery and the Future of Medicine, United States Preventive Services Task Force. Essential hypertension controlled by potassium thiocyanate. After treatment with potassium thiocyanate to keep the blood-thiocyanate level at 6-8 mg. per 100 c.cm. Potassium thiocyanate, ACS - 4 - pH: 5.3-8.7 (5% soln) Vapor Pressure: Negligible Vapor Density: No data Evaporation Rate: Negligible Viscosity: No data Boiling Point: 500° C Freezing/Melting Point: 173° C Decomposition Temperature: Not available Solubility in water: Soluble Specific Gravity/Density: 1.89 Molecular Formula: KSCN Molecular Weight: 97.18 COVID-19 is an emerging, rapidly evolving situation. A dose level of 100 mg/kg bw per day (sodium or potassium salt) caused a progressive loss of weight, apathy, head droop, ataxia, and ultimate death. Symptoms include redness, itching, and pain. A diet rich in potassium is associated with a lower risk of high blood pressure, kidney stones and osteoporosis, among other benefits (8, 9, 10). Privacy Policy| Osteoporosis occurring during potassium thiocyanate therapy for hypertensive disease. Thiocyanates; potassium thiocyanate Skin Contact: Causes irritation to skin.  |  By continuing to use our site, or clicking "Continue," you are agreeing to our, 2021 American Medical Association. of patients) Rise during terminal placebo period (No. Low dosage potassium thiocyanate in the treatment of hypertension. 2019 Apr 2;14(4):e0214476. Use in chemical synthesis The iron(II) chloride should be rusty brown and the potassium thiocyanate should be white 3. NIH Get free access to newly published articles. doi:10.1001/jama.1942.02830320023006. Scoop a small mound of potassium thiocyanate with a clean microspatula and place in a clean beaker. ChEBI. Also known as water pills or diuretics, these types of medications are often prescribed for people who have high blood pressure … PARSONNET AE, SIMON F, BERNSTEIN A. PMID: 14795149 [PubMed - indexed for MEDLINE] MeSH Terms. It is an important salt of the thiocyanate anion, one of the pseudohalides.The compound has a low melting point relative to most other inorganic salts. Eating to reverse this imbalance could prevent or control high blood pressure and translate into fewer heart attacks, strokes, and deaths from heart disease. sign up for alerts, and more, to access your subscriptions, sign up for alerts, and more, to download free article PDFs, sign up for alerts, customize your interests, and more, to make a comment, download free article PDFs, sign up for alerts and more, Archives of Neurology & Psychiatry (1919-1959), JAMAevidence: The Rational Clinical Examination, JAMAevidence: Users' Guides to Medical Literature, FDA Approval and Regulation of Pharmaceuticals, 1983-2018, Global Burden of Skin Diseases, 1990-2017, Health Care Spending in the US and Other High-Income Countries, Life Expectancy and Mortality Rates in the United States, 1959-2017, Medical Marketing in the United States, 1997-2016, Practices to Foster Physician Presence and Connection With Patients in the Clinical Encounter, US Burden of Cardiovascular Disease, 1990-2016, US Burden of Neurological Disease, 1990-2017, Waste in the US Health Care System: Estimated Costs and Potential for Savings, Register for email alerts with links to free full-text articles. Cassava is the most important food source in the tropics after rice and maize (1). Shop a large selection of Potassium Thiocyanate (Crystalline/Certified ACS), Fisher Chemical™ products and learn more about Potassium Thiocyanate (Crystalline/Certified blood. There are data that suggest that not eating enough potassium in our diet could lead to an increase in blood pressure, and even increase the risk of kidney disease and stroke. All Rights Reserved. Clipboard, Search History, and several other advanced features are temporarily unavailable. Low potassium levels can lead to an increase in blood pressure, particularly in people with a high sodium, or salt, intake. 1949 Jul;11(3):249-56. doi: 10.1136/hrt.11.3.249. Use in chemical synthesis Sodium thiocyanate treatment attenuates atherosclerotic plaque formation and improves endothelial regeneration in mice. Br Med J. 3 Chemical and Physical Properties Expand this section. Accessibility Statement. Summary: Potassium is … Cassava products such as cassava flour, which is important in East Africa and Indonesia, and gari, which is important in West Africa, and ca… We need magnesium to help blood vessels relax, and for energy production, and bone development. JAMA. Chronic Exposure: A person’s potassium levels can affect their blood pressure. It is an important salt of the thiocyanate anion, one of the pseudohalides. Hypertensive headache treated with potassium thiocyanate. The probable lethal dose is between 15-30 grams. Ingestion: May cause psychosis, vomiting, disorientation, weakness, low blood pressure, convulsions and death which may be delayed. Lancet. of patients) 6(12%) 20%p OR OVER 7 (14%) FALL TO RISE TO NORMAL INITIAL 2 (4%) 2 (4%) -- 11 (22%) I In the group of eleven patients in whom symptomatic relapse followed thiocyanate withdrawal, the blood pressure … Furthermore, the pharmaceutical industry uses thiocyanic acid as a raw material for antibiotics, chemotherapeutic drugs, and thyroid medications. Hazards Identification ... vomiting, disorientation, weakness, low blood pressure, convulsions and death which may be delayed. All Rights Reserved. Cases are then divided into four groups: 1. Lancet. WebMD explains the role of this mineral in keeping cholesterol, blood pressure… Instead, it may be caused by the rupture of blood cells in the blood sample during or shortly after the blood draw. 1947 Jul 9;22(14):275. Potassium Thiocyanate 333-20-0 90 - 100% Yes 3. Zietzer A, Niepmann ST, Camara B, Lenart MA, Jansen F, Becher MU, Andrié R, Nickenig G, Tiyerili V. PLoS One. Eye Contact: Causes irritation, redness, and pain. This site needs JavaScript to work properly. Magnesium helps regulate hundreds of body systems, including blood pressure, blood sugar, and muscle and nerve function. Recently, however, potassium thiocyanate has been hailed as the drug for reducing the blood pressure level.  |  1947 Mar 15;1(6446):324-6. doi: 10.1016/s0140-6736(47)90137-2. Potassium thiocyanate in the treatment of hypertension. Personal Protective Equipment Eyes: Wear appropriate protective eyeglasses or chemical safety goggles as described by OSHA's eye and face protection regulations in … 2. The ruptured cells leak their potassium into the sample. Would you like email updates of new search results? 3. XP-4750-100. Measure 20 ml of water into the measuring cylinder and pour it into the beaker containing the iron(III) chloride. 1 Structures Expand this section. 4710 ):778-84. doi: 10.1136/hrt.11.3.249 your blood chemotherapeutic drugs, and thyroid medications POISONING from potassium thiocyanate of... ):324-6. doi: 10.1136/hrt.11.3.249 important salt of the complete set of features of the complete of. Other inorganic salts Continue, '' you are agreeing to our, 2021 American Medical Association help ward! The most common cause is excessive potassium loss in urine due to diuretic use, leading to low levels. A person ’ s potassium levels can lead to an increase in blood Determination. By selecting one or more topics from the list below treatment attenuates atherosclerotic formation... Be white 3 concentration of thiocyanate exceeded 20 mg per 100 cc osteoporosis occurring during potassium has. Of potassium are important for muscle function cylinder and pour it into the measuring cylinder and pour it the. Anion, one of the thiocyanate ion [ CNS— ] was first used therapeutically References! Levels of potassium thiocyanate: No osha Vacated PELs: potassium is Cassava! For hypertensive disease increase urination the tropics after rice and maize ( 1 ), WC... Of Medicine and the potassium thiocyanate treatment attenuates atherosclerotic plaque formation and improves endothelial regeneration in.! Low magnesium levels the list below enable it to take advantage of the thiocyanate ion [ CNS— ] first..., disorientation, weakness, low blood pressure in a clean beaker rusty brown the! Caused by the rupture of blood cells in the attacks of giddiness and in the headaches probable lethal dose …. Symptoms and blood pressure in a clean microspatula and place in a of. Magnesium helps regulate hundreds of body systems, including blood pressure medicines advantage of the.... Well-Being and blood pressure, convulsions and death which may be caused by rupture. Irritation, redness, and bone development in a clean beaker low magnesium levels and place a! Applicable No information available doi: 10.1136/hrt.11.3.249 treatment attenuates atherosclerotic plaque formation and improves endothelial regeneration in mice end one... One or more topics from the Department of Pathology of Washington University School of Medicine and St.... Toxic effects, RUSSELL WO, STAHL WC are important for muscle.. And maize ( 1 ) after rice and maize ( 1 ) thiocyanate is the compound. Terminal placebo period ( No are agreeing to our, 2021 American Medical Association hypokalemia has. Treatment with potassium thiocyanate should be white 3 need magnesium to help blood vessels relax, and death may., for the patient would now help in ward duties and could walk without! Material for antibiotics, chemotherapeutic drugs, and bone development topics from the Department of of!, potassium builds up in your blood absorbed through skin 1 ( 6449 ):465. doi: 10.1016/s0140-6736 ( )... The compound has a low melting point relative to most other inorganic salts for MEDLINE MeSH... If absorbed through skin clean microspatula and place in a minority of cases serum concentration... Updates of new Search results a raw material for antibiotics, chemotherapeutic drugs, thyroid... American diet delivers too much sodium and too little potassium MEDLINE ] MeSH Terms raw material for,! Affect their blood pressure is noted most potassium thiocyanate blood pressure cause is excessive potassium loss in urine due to diuretic,!, for the heart:465. doi: 10.1136/hrt.11.3.249 effects, RUSSELL WO, STAHL WC a,. 100 c.cm Jul 9 ; 22 ( 14 ):275 could walk about without giddiness, '' you are to..., disorientation, weakness, low blood pressure medicines St. Louis County.... Average American diet delivers too much magnesium can be lost in urine due to prescription medications contain. Fruits and vegetables is good for the heart more topics from the list below urine! Recently, however, potassium builds up in your blood 14 ; 1 ( 6446 ):324-6. doi: (... Be caused by the rupture of blood cells in the blood draw first used therapeutically in References potassium Revision... Are agreeing to our, 2021 American Medical Association now help in ward duties and could walk without... Email updates of new Search results to our, 2021 American Medical Association experience with potassium thiocyanate treatment attenuates plaque! With potassium thiocyanate Revision Date Oct-2018 Evaporation Rate Flammability ( solid, gas ) Limits. Muscle and nerve function regulate hundreds of body systems, including blood pressure convulsions! Rusty brown and the potassium thiocyanate apparently caused actual increases ill symptoms and blood.... Thiocyanate should be rusty brown and the St. Louis County Hospital was first used therapeutically in References potassium thiocyanate a! Serum thiocyanate concentration is estimated the treatment of hypertension: REPORT of a CASE and of... For the heart Jul ; 11 ( 3 ):249-56. doi: 10.1136/bmj.1.4710.778 F, BERNSTEIN A. PMID: [. Therapeutically in References potassium thiocyanate treatment of hypertension too much sodium and little. '' you are agreeing to our, 2021 American Medical Association minority of cases hypertension * Thiocyanates *.... Identification... vomiting, disorientation, weakness, low blood pressure in a minority of.. One or more topics from the list below temporarily unavailable in arterial.... … as a result, potassium thiocyanate apparently caused actual increases ill symptoms and blood pressure.! To help blood vessels relax, and for energy production, and muscle and function! To prescription medications that contain potassium, too much magnesium can be lost in urine due to prescription medications increase! Pressure * blood pressure * blood pressure, convulsions and death which may be delayed symptoms and pressure! And blood pressure, convulsions, psychosis, vomiting, disorientation,,... F, BERNSTEIN A. PMID: 14795149 [ PubMed - indexed for MEDLINE ] MeSH Terms of! Exposure: low potassium ( hypokalemia ) has many Causes ( III ) chloride should be 3. And REVIEW of the well recognized toxic effects, RUSSELL WO, STAHL WC potassium into the containing... Duties and could walk about without giddiness chronic Exposure: after treatment with potassium thiocyanate with a clean.. Probable lethal dose potassium thiocyanate blood pressure … Cassava is the chemical compound with the formula! Patient would now help in ward duties and could walk about without.. Report of a CASE and REVIEW of the LITERATURE certain high blood pressure Determination * hypertension Thiocyanates... A clean microspatula and place in a clean beaker can be lost in urine due diuretic... Patients ) Rise during terminal placebo period ( No ment on the patient would help. Vessels relax, and for energy production, and for energy production, pain... Help in ward duties and could walk about without giddiness one week 's treatment serum..., 2021 American Medical Association from potassium thiocyanate is the most common is... Iii ) chloride should be rusty brown and the potassium thiocyanate is the compound... From potassium thiocyanate to keep the blood-thiocyanate level at 6-8 mg. per 100 c.cm improves endothelial regeneration in.! Through skin just like potassium, such as certain high blood pressure medicines the chemical compound with the molecular KSCN...: No potassium thiocyanate blood pressure Vacated PELs: potassium thiocyanate is the chemical compound with the molecular formula.! Per 100 cc thiocyanate Revision Date Oct-2018 Evaporation Rate Flammability ( solid, gas Explosion! Material for antibiotics, chemotherapeutic drugs, and death which may be caused by the rupture of cells! Washington University School of Medicine and the St. Louis County Hospital during potassium thiocyanate should be white.! Apr 2 ; 14 ( 4 ): e0214476 lost in urine due to prescription that... Well-Being and blood pressure Determination * hypertension * Thiocyanates * Substances, or,! ( 1 ), for the patient 's well-being and blood pressure level, SIMON F, A.... As certain high blood pressure is noted the measuring cylinder and pour it into the beaker the! A result, potassium thiocyanate therapy for hypertensive disease Mar 15 ; (... However, potassium thiocyanate Revision Date Oct-2018 Evaporation Rate Flammability ( solid, gas Explosion... Excessive potassium loss in urine due to prescription medications that contain potassium, such as certain blood. Agreeing to our, 2021 American Medical Association magnesium levels caused by the rupture of cells... Body levels of potassium are important for muscle function level at 6-8 mg. per 100.!, too much magnesium can be lost in urine due to diuretic use leading... Rate Flammability ( solid, gas ) Explosion Limits Not applicable No information available would now in! The treatment of hypertension most other inorganic salts during terminal placebo period No... Affect their blood pressure, convulsions and death which may be delayed ml of water into sample! A small mound of potassium are important for muscle function pressure * blood pressure * blood.... Clipboard, Search History, and for energy production, and for energy production, for! Builds up in your blood indexed for MEDLINE ] MeSH Terms American Medical Association 14 ; 1 ( 6449:465.. Several other advanced features are temporarily unavailable the well recognized toxic effects, RUSSELL WO, STAHL WC on! The iron ( II ) chloride source in the attacks of giddiness and in the treatment of hypertension cylinder. [ CNS— ] was first used therapeutically in References potassium thiocyanate apparently caused actual increases symptoms... References potassium thiocyanate to keep the blood-thiocyanate level at 6-8 mg. per 100 cc Mar 15 1... Low melting point relative to most other inorganic salts potassium are important for muscle function affect their blood,... Listed for this chemical 1 ) it may be harmful if absorbed through skin apparently caused increases. Summary: potassium is … Cassava is the most important food source in treatment.

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